Vibrant, Interactive, & Inclusive Department.Investigating key physiology and neurobiology questions using diverse approaches
Physiology and Neurobiology
We carry out research and education that is innovative, collaborative, and centered on cutting-edge science. We bring together researchers and educators focused on the molecular, cellular, and circuit-based mechanisms that underlie diverse functions orchestrated by the brain and body. By integrating work across the spectrum of Physiology and Neurobiology, we aim to advance our understanding of brain-body functions and interactions under normal conditions and disease.
A Message From The Department Head
'Welcome to the Department of Physiology and Neurobiology (PNB) website at the University of Connecticut. PNB, formerly the Physiology section of the Department of Biological Sciences, was established as a department in 1986. Today, PNB is one of the twenty-five departments in the College of Liberal Arts and Sciences. We are a vibrant, collegial, interactive, and inclusive department, housed in the Pharmacy/Biology and Torrey Life Science Buildings on the UConn Storrs main campus.
PNB is the home to twenty-two faculty members with diverse cultural and educational background who are investigating fundamental physiology and neurobiology questions using a variety of approaches. Research areas include neurobiology, reproductive biology, development, RNA processing, and human disease models, as well as research on STEM education. We also oversee the Bioscience Electron Microscopy Laboratory, which provides service and training to users across the Storrs campus.'READ FULL MESSAGE
'Welcome to the Department of Physiology and Neurobiology (PNB) website at the University of Connecticut. PNB, formerly the Physiology section of the Department of Biological Sciences, was established as a department in 1986. Today, PNB is one of the twenty-five departments in the College of Liberal Arts and Sciences. We are a vibrant, collegial, interactive, and inclusive department, housed in the Pharmacy/Biology and Torrey Life Science Buildings on the UConn Storrs main campus.'READ FULL MESSAGE
KCNQ2/3 Gain-of-Function Variants and Cell Excitability: Differential Effects in CA1 versus L2/3 Pyramidal Neurons
Varghese N, Moscoso B, Chavez A, Springer K, Ortiz E, Soh H, Santaniello S, Maheshwari A, Tzingounis AV.
J Neurosci. 2023 Sep 20;43(38):6479-6494. doi: 10.1523/JNEUROSCI.0980-23.2023. Epub 2023 Aug 22.
Regulation of LRRK2 mRNA stability by ATIC and its substrate AICAR through ARE-mediated mRNA decay in Parkinson's disease
Liu Q, Zhu D, Li N, Chen S, Hu L, Yu J, Xiong Y.
EMBO J. 2023 Aug 1;42(15):e113410. doi: 10.15252/embj.2022113410. Epub 2023 Jun 27.
KCNQ2 channels regulate the population activity of neonatal GABAergic neurons ex vivo
Hou B, Santaniello S, Tzingounis AV.
Front Neurol. 2023 Jun 20;14:1207539. doi: 10.3389/fneur.2023.1207539. eCollection 2023.
The bHLH-PAS transcriptional complex Sim:Tgo plays active roles in late oogenesis to promote follicle maturation and ovulation
Oramas R, Knapp EM, Zeng B, Sun J.
Development. 2023 Jun 15;150(12):dev201566. doi: 10.1242/dev.201566. Epub 2023 Jun 14.
Minor intron splicing is critical for survival of lethal prostate cancer
Augspach A, Drake KD, Roma L, Qian E, Lee SR, Clarke D, Kumar S, Jaquet M, Gallon J, Bolis M, Triscott J, Galván JA, Chen Y, Thalmann GN, Kruithof-de Julio M, Theurillat JP, Wuchty S, Gerstein M, Piscuoglio S, Kanadia RN, Rubin MA.
Mol Cell. 2023 Jun 15;83(12):1983-2002.e11. doi: 10.1016/j.molcel.2023.05.017. Epub 2023 Jun 8.
Perspectives on the basis of seizure-induced respiratory dysfunction
Mulkey DK, Milla BM.
Front Neural Circuits. 2022 Dec 20;16:1033756. doi: 10.3389/fncir.2022.1033756. eCollection 2022. PMID: 36605420.
Myotubularin functions through actomyosin to interact with the Hippo pathway.
Hu L, Brichalli W, Li N, Chen S, Cheng Y, Liu Q, Xiong Y, Yu J.
EMBO Rep. 2022 Dec 6;23(12):e55851. doi: 10.15252/embr.202255851. Epub 2022 Oct 26. PMID: 36285521
The mammalian nodal action potential: new data bring new perspectives
Tanner GR, Tzingounis AV.
Adv Physiol Educ. 2022 Dec 1;46(4):693-702. doi: 10.1152/advan.00171.2021. Epub 2022 Sep 29. PMID: 36173340
The small RNA landscape is stable with age and resistant to loss of dFOXO signaling in Drosophila.
Gartland S, Zeng B, Marr MT
PLoS One. 2022 Nov 16;17(11):e0273590. doi: 10.1371/journal.pone.0273590. eCollection 2022. PMID: 36383505
Presentation and integration of multiple signals that modulate oligodendrocyte lineage progression and myelination.
Fekete CD, Nishiyama A.
Front Cell Neurosci. 2022 Nov 14;16:1041853. doi: 10.3389/fncel.2022.1041853. eCollection 2022.
A common framework for mouse hypothalamic cell atlases.
Nat Metab. 2022 Oct;4(10):1227-1228. doi: 10.1038/s42255-022-00660-3.
- WCSU’s Sophia Chiaia worked this summer in Dr. Jianjun Sun’s LabWestern Connecticut State University’s Sophia Chiaia participated in a summer SURF program in Dr. Jianjun Sun’s laboratory. Sophia is a Kathwari Honors Program Scholar. She is an undergraduate Biology major, class of 2024.