Recent Publications

• Advancements in Immunity and Dementia Research: Highlights from the 2023 AAIC Advancements: Immunity Conference December 18, 2024
  The immune system is a key player in the onset and progression of neurodegenerative disorders. While brain resident immune cell-mediated neuroinflammation and peripheral immune cell (eg, T cell) infiltration into the brain have been shown to significantly contribute to Alzheimer's disease (AD) pathology, the nature and extent of immune responses in the brain in the […]
  Courtney M Kloske, Simin Mahinrad, Christopher J Barnum, Andre F Batista, Elizabeth M Bradshaw, Brittany Butts, Maria C Carrillo, Paramita Chakrabarty, Xiaoying Chen, Suzanne Craft, Sandro Da Mesquita, Luke C Dabin, Davangere Devanand, Violeta Duran-Laforet, Wassim Elyaman, Elizabeth E Evans, Patricia Fitzgerald-Bocarsly, Kate E Foley, Ashley S Harms, Michael T Heneka, Soyon Hong, Yu-Wen A Huang, Stephanie Jackvony, Laijun Lai, Yann Le Guen, Cynthia A Lemere, Shane A Liddelow, Alfonso Martin-Peña, Anna G Orr, Francisco J Quintana, Grace D Ramey, Jessica E Rexach, Stacey J S Rizzo, Claire Sexton, Alice S Tang, Jose G Torrellas, Andy P Tsai, Lynn van Olst, Keenan A Walker, Whitney Wharton, Malú Gámez Tansey, Donna M Wilcock
• Honoring the legacy of Joseph E. LeDoux: introduction to the Special Issue December 14, 2024
  No abstract
  Daniela Schiller, Joshua Johansen, Linnaea Ostroff
• CalDAG-GEFI acts as a guanine nucleotide exchange factor for LRRK2 to regulate LRRK2 function and neurodegeneration November 22, 2024
  Mutations in LRRK2 are the most common genetic cause of Parkinson's disease (PD). LRRK2 protein contains two enzymatic domains: a GTPase (Roc-COR) and a kinase domain. Disease-causing mutations are found in both domains. Now, studies have focused largely on LRRK2 kinase activity, while attention to its GTPase function is limited. LRRK2 is a guanine nucleotide-binding […]
  Qinfang Liu, Bingxu Huang, Noah Guy Lewis Guiberson, Shifan Chen, Dong Zhu, Gang Ma, Xin-Ming Ma, Jill R Crittenden, Jianzhong Yu, Ann M Graybiel, Ted M Dawson, Valina L Dawson, Yulan Xiong
• Actomyosin contraction in the follicular epithelium provides the major mechanical force for follicle rupture during <em>Drosophila</em> ovulation September 18, 2024
  Ovulation is critical for sexual reproduction and consists of the process of liberating fertilizable oocytes from their somatic follicle capsules, also known as follicle rupture. The mechanical force for oocyte expulsion is largely unknown in many species. Our previous work demonstrated that Drosophila ovulation, as in mammals, requires the proteolytic degradation of the posterior follicle […]
  Stella E Cho, Wei Li, Andrew M Beard, Jonathan A Jackson, Risa Kiernan, Kazunori Hoshino, Adam C Martin, Jianjun Sun
• C1ql1 expression in oligodendrocyte progenitor cells promotes oligodendrocyte differentiation September 11, 2024
  Myelinating oligodendrocytes arise from the stepwise differentiation of oligodendrocyte progenitor cells (OPCs). Approximately 5% of all adult brain cells are OPCs. Why would a mature brain need such a large number of OPCs? New myelination is possibly required for higher-order functions such as cognition and learning. Additionally, this pool of OPCs represents a source of […]
  Zeynep M Altunay, Joyshree Biswas, Hiu W Cheung, Robert S Pijewski, Lucille E Papile, Yetunde O Akinlaja, Andrew Tang, Lyndsay C Kresic, Alexander D Schouw, Maksym V Ugrak, Keaven Caro, Perla A Peña Palomino, Susanne Ressl, Akiko Nishiyama, Stephen J Crocker, David C Martinelli
• Glial modulation of synapse development and plasticity: oligodendrocyte precursor cells as a new player in the synaptic quintet September 11, 2024
  Synaptic communication is an important process in the central nervous system that allows for the rapid and spatially specified transfer of signals. Neurons receive various synaptic inputs and generate action potentials required for information transfer, and these inputs can be excitatory or inhibitory, which collectively determines the output. Non-neuronal cells (glial cells) have been identified […]
  Yetunde O Akinlaja, Akiko Nishiyama
• Ultraplex microscopy: versatile highly-multiplexed molecular labeling and imaging across scale and resolution September 4, 2024
  The molecular organization of cells and tissue is challenging to study due to the inefficiency of multiplexed molecular labeling methods and the limited options for combining microscopy modalities in a single specimen, especially when high spatial resolution is needed. Here we describe ultraplex microscopy, which combines serial multiplexing, ultrathin sectioning, and reversible embedding to circumvent […]
  Janeth Pérez-Garza, Jairo Orea, Zachary Deane, Gianna Raimondi, Rebecca Tripp, Imani Charles, Linnaea Ostroff
• Evaluation of Pain-Associated Behavioral Changes in Monoiodoacetate-Induced Osteoarthritic Rats Using Dynamic Weight Bearing Analysis August 29, 2024
  Pain is the primary clinical indication of osteoarthritis (OA), and behavioral assessments in rodent pain models are widely used to understand pain patterns. These preclinical pain assessments can also help us to understand the effectiveness of emerging therapeutics for prolonged OA pain management. Along with evoked methods like mechanical allodynia and thermal hyperalgesia, non-evoked methods […]
  Devika Kishnan, Erick Orozco Morato, Aydin Calsetta, Kyle M Baumbauer, Lakshmi S Nair
• LRRK2 in Parkinson's disease: upstream regulation and therapeutic targeting August 17, 2024
  Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common causes of Parkinson's disease (PD) to date. Dysfunction in LRRK2 enzymatic activities and elevated protein levels are associated with the disease. How is LRRK2 activated, and what downstream molecular and cellular processes does LRRK2 regulate? Addressing these questions is crucial to decipher the disease […]
  Yulan Xiong, Jianzhong Yu
• Ventricular-subventricular zone stem cell niche adaptations in a mouse model of post-infectious hydrocephalus August 15, 2024
  Congenital post-infectious hydrocephalus (PIH) is a condition characterized by enlargement of the ventricular system, consequently imposing a burden on the associated stem cell niche, the ventricular-subventricular zone (V-SVZ). To investigate how the V-SVZ adapts in PIH, we developed a mouse model of influenza virus-induced PIH based on direct intracerebroventricular injection of mouse-adapted influenza virus at […]
  Julianna Herman, Nicole Rittenhouse, Francesca Mandino, Mushirah Majid, Yuxiang Wang, Amelia Mezger, Aidan Kump, Sumeet Kadian, Evelyn M R Lake, Paulo H Verardi, Joanne C Conover
• The prevalence and patterns of hearing loss in Jordan: A cross-sectional study August 15, 2024
  CONCLUSION: The rate of hearing loss in Jordan is higher than worldwide prevalence, which was assumed to be due to genetic factors impacting the auditory system. These findings will assist in creating effective hearing conservation programs to reasonably prevent or minimize the spread of hearing loss in Jordan.
  Safa Alqudah, Margaret Zuriekat, Saja Hassan, Heba Mahafdeh, Zainab Alqudah, Aya Shatarah, Ghufran Smadi
• Neural Delays in Processing Speech in Background Noise Minimized after Short-Term Auditory Training July 26, 2024
  Background noise disrupts the neural processing of sound, resulting in delayed and diminished far-field auditory-evoked responses. In young adults, we previously provided evidence that cognitively based short-term auditory training can ameliorate the impact of background noise on the frequency-following response (FFR), leading to greater neural synchrony to the speech fundamental frequency(F0) in noisy listening conditions. […]
  Erika Skoe, Nina Kraus
• Myelin basic protein mRNA levels affect myelin sheath dimensions, architecture, plasticity, and density of resident glial cells July 18, 2024
  Myelin Basic Protein (MBP) is essential for both elaboration and maintenance of CNS myelin, and its reduced accumulation results in hypomyelination. How different Mbp mRNA levels affect myelin dimensions across the lifespan and how resident glial cells may respond to such changes are unknown. Here, to investigate these questions, we used enhancer-edited mouse lines that […]
  Hooman Bagheri, Hana Friedman, Amanda Hadwen, Celia Jarweh, Ellis Cooper, Lawrence Oprea, Claire Guerrier, Anmar Khadra, Armand Collin, Julien Cohen-Adad, Amanda Young, Gerardo Mendez Victoriano, Matthew Swire, Andrew Jarjour, Marie E Bechler, Rachel S Pryce, Pierre Chaurand, Lise Cougnaud, Dajana Vuckovic, Elliott Wilion, Owen Greene, Akiko Nishiyama, Anouk Benmamar-Badel, Trevor Owens, Vladimir Grouza, Marius Tuznik, Hanwen Liu, David A Rudko, Jinyi Zhang, Katherine A Siminovitch, Alan C Peterson
• 3D Biological/Biomedical Image Registration with enhanced Feature Extraction and Outlier Detection July 15, 2024
  In various applications, such as computer vision, medical imaging and robotics, three-dimensional (3D) image registration is a significant step. It enables the alignment of various datasets into a single coordinate system, consequently providing a consistent perspective that allows further analysis. By precisely aligning images we can compare, analyze, and combine data collected in different situations. […]
  Sahand Hamzehei, Jun Bai, Gianna Raimondi, Rebecca Tripp, Linnaea Ostroff, Sheida Nabavi
• KATNAL2 mutations link ciliary dysfunction to hydrocephalus and autism July 15, 2024
  No abstract
  Videep Soni, Joseph J LoTurco